Senior Chemist Synthetic Chemistry

Exciting opportunity to join a well-funded start-up in San Diego

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A bit about us:

My client is a newly launched next-wave genetic medicine company focusing on base editing of mRNA transcripts. They discover and develop innovative therapeutics that can utilize a family of endogenous enzymes called adenosine deaminase acting on RNA (ADAR) to precisely target and correct single point mutations on a mRNA, thus the production of desired and functional protein is restored. Their vision is to provide effective and safe therapeutics to patients who suffer from currently undruggable diseases.

They are well-financed with backup from a group of renowned VC funds, and our brand-new laboratory is located in San Diego, California.

Why join us?

State-of-the art facility in San Diego, CA
Opportunities for advancement
Excellent benefits package
Stock options

Job Details

Senior Chemist, Synthetic Chemistry

Job Description:

We are looking for experienced and motivated Chemist(s) to join our Discovery Chemistry group to advance/drive cutting-edge RNA editing drug discovery programs.


Utilize cutting-edge synthetic methodologies and techniques to design and execute efficient syntheses of target compounds for existing chemical series and novel series
Independently conduct multi-step synthesis and optimization through effective reaction planning, troubleshooting, and systematic analysis
Purify and characterize compounds using a variety of techniques including chromatography, crystallization, trituration, LCMS, NMR, etc.
Enable chemistry via new technologies
Potentially help set up and manage a synthetic chemistry lab
Maintain the lab instruments including HPLC, ISCO, lyophilizer etc.
Maintain all appropriate corporate standards for lab safety and hazardous material management; execute daily chemistry operations with an approach designed to minimize risks and hazard waste streams
Maintain lab notebook, instrument and inventory records in accord with department guidance and regulatory requirements
Prepare and present summaries of work for department and project meetings

Requirements / Qualifications:

PhD in synthetic organic chemistry or medicinal chemistry with 0-5 years of experience in pharmaceutical or biotech industry
Demonstrated track record of innovative scientific publications in high-profile journals or patents
Superior laboratory skills and awareness of laboratory safety
Excellent oral and written communication skills


This is a full-time position, Monday-Friday 8am – 5pm
Pay commensurate with experience
401k with company match
Medical, Dental, Vision, Life Insurance, FSA, Employee Assistance Program, Employee Discounts
Performance based bonuses
PTO and Holidays

Work authorization:

United States (Required)
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Job Details
Managed by Jobot Pro
San Diego, CA
Job Type
$65,000 - $130,000