Principal Scientist - Virology/Vaccine Vector Design

Vaccine Vector Design and Early Development Lab! Relocation allowance!

  • Brooklyn, NY
  • $140,000 - $150,000
  • Managed by Jobot Pro: Andrea Ankarlo
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A bit about us:

We are a rapidly growing scientific research organization that works to develop vaccines and antibodies for HIV, tuberculosis, and infectious diseases! Having been around for over 20 years, we have grown to develop facilities in over 5 countries, and topped over $85 million in revenue in the past 2 years.

Why join us?

  • Generous PTO plan, 11 paid holidays, and year-end office closure!
  • 401(k) with EXCELLENT company match
  • Full Benefits; multiple plans to choose from
  • FSA/HSA options
  • Annual bonus!

Job Details

Job Title: Principal Scientist, Vaccine Vector Design and Early Development Lab

This position will play a key role in the Emerging Infectious Diseases portfolio which currently encompasses development of prophylactic viral vaccines against Lassa virus, Marburg virus, HIV-1 and SARS-COV2 and others.

This is an excellent opportunity to directly participate in early phase viral vaccine development and work together with teams that are engaged in cGMP manufacturing and nonclinical safety evaluation as we progress products into clinical trials. As the Vector Design team lead, the Scientist designs, generates, and characterizes novel live replicating viral vaccines targeting emerging infectious diseases with specific focus on recombinant vesicular stomatitis virus (VSV)-based vaccine vectors. The Scientist supervises the operation of the EDL, which is responsible for the generation of materials compliant with cGMP manufacturing and will support preclinical studies and clinical product development.

Key Responsibilities:
  • Lead, manage, and mentor a research team of 4-6 members to perform independent and original research
  • Manage work associated with vaccine development:
o Design, generate and characterize VSV-based viral vectors expressing diverse viral antigens.
o Assist in development of analytical assays to evaluate viral vectors and vaccine material.
o Remain current in scientific literature and apply technical and functional knowledge to continually optimize current procedures.
o Analyze, interpret, and present data.
o Trouble-shoot and solve technical challenges.

  • Manage work associated with vaccine research and early development:
o Oversee the operations of the EDL and ensure timelines and milestones are met.
o Establish methodology and procedures to produce cGMP compliant material. Draft, review and approve working instructions, SOPs and other documentation associated with each vaccine lot.
o Participate in upstream and downstream process development for vaccine production in the laboratory and participate in technology transfer to contract manufacturing organizations.
o Maintain communication with Quality Assurance (QA) and Chemistry Manufacturing Controls (CMC) teams to ensure the EDL operation is compliant with cGLP.
o Represent EDL as the SME on cross-functional teams and meetings with stakeholders.
o Oversee the infectious material transfer to global collaborators or CMOs and ensure that shipments are compliant with international regulations.

Education and Experience:
  • PhD in Virology, Molecular Biology, Immunology, or related field from a recognized Institution is required.
  • 5+ years of post-graduate experience in virology and molecular biology is required.
  • Experience conducting or leading viral vaccine efforts is highly preferred.

Qualification and skills:
  • Experience managing and leading research scientists and teams is required.
  • Experience managing research projects with time-sensitive milestones and deliverables is required.
  • Hands-on laboratory experience with basic and advanced techniques associated with virology, molecular biology, and recombinant virus vector development.
  • Experience with virus purification technology based on ultrafiltration is preferred.
  • Willingness to manage a research team as well as contribute to bench work as needed.
  • Track record demonstrating ability to assume responsibility for composing components of complex documents such as IND submission packages, manuscripts, patents, funder reports, and grant applications is required.

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Job Details
Managed by Jobot Pro
Brooklyn, NY
Job Type
$140,000 - $150,000